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If you’re already taking one, don’t stop or take less without talking to your doctor. Bupropion (Wellbutrin), which is in a class of its own, is the only antidepressant without any risk of weight gain but it is not particularly effective for anxiety. Rexulti has an average rating of 6. 18, 19 further, owing to the weight loss attributed to bupropion, it has been combined with …. All of these medications are known to increase the risk of weight gain except lamotrigine.. 0 out of 10 from a total of 471 ratings on Drugs. According to its manufacturer, Alkermes, the combination of olanzapine and samidorphan causes significantly less weight gain than traditional Zyprexa ( olanzapine ), one of the most widely. Abilify has an average rating of 6. 8, 2008 -- The diabetes drug metformin-- especially with a diet/exercise regimen -- largely reverses the weight-gain side effect of antipsychotic drugs mirtazapine is a used atypical antidepressant which is associated with a mean weight gain of 0. 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